Cargando…

Intra-tumoral drug concentration mapping within solid tumor micro-milieu using in-vitro model and doxorubicin as a model drug

In contrast to plasma pharmacokinetics, intratumoral pharmacokinetics of doxorubicin (DOX) determines its spatial anti-tumoral activity. Three-dimensional multicellular layers (MCL) model for solid tumors present optimum experimental platform for studying the intratumoral pharmacokinetics of DOX. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Abd, Ahmed M., Khedr, Alaa, Atteiah, Salah G., Al-Abbasi, Fahad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292875/ https://www.ncbi.nlm.nih.gov/pubmed/32550808 http://dx.doi.org/10.1016/j.jsps.2020.05.001

Ejemplares similares

Comparative effects of free doxorubicin, liposome encapsulated doxorubicin and liposome co-encapsulated alendronate and doxorubicin (PLAD) on the tumor immunologic milieu in a mouse fibrosarcoma model
por: Islam, Md. Rakibul, et al.
Publicado: (2022)

Multistep, effective drug distribution within solid tumors
por: Shemi, Amotz, et al.
Publicado: (2015)

A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors
por: Eikenberry, Steffen
Publicado: (2009)

Tumor Milieu Controlled by RB Tumor Suppressor
por: Kitajima, Shunsuke, et al.
Publicado: (2020)

Modelling of combination therapy using implantable anticancer drug delivery with thermal ablation in solid tumor
por: Al-Zu’bi, Muneer, et al.
Publicado: (2020)

Migration of mesenchymal stem cells to tumor xenograft models and in vitro drug delivery by doxorubicin
por: Kalimuthu, Senthilkumar, et al.
Publicado: (2018)

Anticancer Profiling for Coumarins and Related O-Naphthoquinones from Mansonia gagei against Solid Tumor Cells In Vitro
por: Baghdadi, Mohammed A., et al.
Publicado: (2018)

The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models
por: Maser, Ilona-Petra, et al.
Publicado: (2020)

Multiscale Kinetic Modeling of Liposomal Doxorubicin Delivery Quantifies the Role of Tumor and Drug-Specific Parameters in Local Delivery to Tumors
por: Hendriks, B S, et al.
Publicado: (2012)

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
por: Millard, Marie, et al.
Publicado: (2017)

Barriers to drug delivery in solid tumors
por: Sriraman, Shravan Kumar, et al.
Publicado: (2014)

TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu
por: Kunert, Andre, et al.
Publicado: (2013)

Effect of tumor shape and size on drug delivery to solid tumors
por: Soltani, M, et al.
Publicado: (2012)

High-Dose Intermittent Treatment with the Multikinase Inhibitor Sunitinib Leads to High Intra-Tumor Drug Exposure in Patients with Advanced Solid Tumors
por: Gerritse, Sophie L., et al.
Publicado: (2022)

Doxorubicin uptake in ascitic lymphoma model: resistance or curability is governed by tumor cell density and prolonged drug retention
por: Zaleskis, Gintaras, et al.
Publicado: (2020)

Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives
por: Shen, Xiaoding, et al.
Publicado: (2023)

Ultrasonic Enhancement of Drug Penetration in Solid Tumors
por: Lai, Chun-Yen, et al.
Publicado: (2013)

Strategies to Increase Drug Penetration in Solid Tumors
por: Choi, Il-Kyu, et al.
Publicado: (2013)

2019–2020 Drug Updates in Solid Tumors
por: Hanna, Kirollos S.
Publicado: (2021)

2018–2019 Drug Updates in Solid Tumors
por: Barbour, Sally
Publicado: (2020)

2020–2021 Drug Updates in Solid Tumors
por: Cambareri, Christine
Publicado: (2022)

2021–2022 Drug Updates in Solid Tumors
por: Hanna, Kirollos
Publicado: (2023)

A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma
por: Elsaady, Shimaa A., et al.
Publicado: (2023)

Magnetic field potential effects on the doxorubicin therapeutic activity in Ehrlich tumor growth
por: Ghannam, Magdy M., et al.
Publicado: (2021)

Developmental Milieu Influences a Gene's Role in Tumor Formation
Publicado: (2004)

NK Cell Interaction With Platelets and Myeloid Cells in the Tumor Milieu
por: Maurer, Stefanie, et al.
Publicado: (2020)

Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology
por: Weddell, Jared, et al.
Publicado: (2020)

The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment
por: Ni, Yanghong, et al.
Publicado: (2021)

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors
por: Gagliardi, Agnese, et al.
Publicado: (2021)

Geriatric drug trials on solid tumor are scarce worldwide
por: Huang, Huiyao, et al.
Publicado: (2023)

Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity
por: Henidi, Hanan A., et al.
Publicado: (2020)

Magnetic resonance spectroscopy — Revisiting the biochemical and molecular milieu of brain tumors
por: Verma, Ashish, et al.
Publicado: (2016)

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
por: Labani-Motlagh, Alireza, et al.
Publicado: (2020)

Tissue Distribution and Efficacy of Gold Nanorods Coupled with Laser Induced Photoplasmonic Therapy in Ehrlich Carcinoma Solid Tumor Model
por: El-Sayed, Mostafa A., et al.
Publicado: (2013)

Systematic Review of Patient-Derived Xenograft Models for Preclinical Studies of Anti-Cancer Drugs in Solid Tumors
por: Koga, Yoshikatsu, et al.
Publicado: (2019)

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
por: Souri, Mohammad, et al.
Publicado: (2021)

Computational Modeling of Combination of Magnetic Hyperthermia and Temperature-Sensitive Liposome for Controlled Drug Release in Solid Tumor
por: Tehrani, Masoud H. H., et al.
Publicado: (2021)

The predictive model for risk of chemotherapy-induced thrombocytopenia based on antineoplastic drugs for solid tumors in eastern China
por: Zhou, Shishi, et al.
Publicado: (2023)

Editorial: Inhibitors of CDK family: New perspective and rationale for drug combination in preclinical models of solid tumors
por: Cavazzoni, Andrea, et al.
Publicado: (2023)

Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity
por: Cappetta, Donato, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mfbs482ic5gmtnt1bnsvbla29l