ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is independent of its autophagy-related activity. Downregulation of ZKSCAN3 is observed in aged...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Huifang, Ji, Qianzhao, Song, Moshi, Ren, Jie, Liu, Zunpeng, Wang, Zehua, Liu, Xiaoqian, Yan, Kaowen, Hu, Jianli, Jing, Yaobin, Wang, Si, Zhang, Weiqi, Liu, Guang-Hui, Qu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293006/
https://www.ncbi.nlm.nih.gov/pubmed/32427330
http://dx.doi.org/10.1093/nar/gkaa425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293006/
https://www.ncbi.nlm.nih.gov/pubmed/32427330
http://dx.doi.org/10.1093/nar/gkaa425

Ejemplares similares