Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes

In the cell cycle, the G(1)/S transition is controlled by the cyclin‐dependent kinase (CDK) 4/6‐cyclin D complex. Constitutive activation of CDK4/6 dysregulates G(1)/S transition, leading to oncogenic transformation. We found that 3 CDK4/6 inhibitors, abemaciclib, ribociclib, and palbociclib, exerte...

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Detalles Bibliográficos
Autores principales: Hino, Hirotsugu, Iriyama, Noriyoshi, Kokuba, Hiroko, Kazama, Hiromi, Moriya, Shota, Takano, Naoharu, Hiramoto, Masaki, Aizawa, Shin, Miyazawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293084/
https://www.ncbi.nlm.nih.gov/pubmed/32304130
http://dx.doi.org/10.1111/cas.14419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293084/
https://www.ncbi.nlm.nih.gov/pubmed/32304130
http://dx.doi.org/10.1111/cas.14419

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