Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Based on the hypothesis that specific inhibition of APC’s anticoagulant but not its cytoprotective activity can be beneficial for hemophilia therapy, 2 types of inhibitory monoclonal antibodies (m...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiao-Yan, Wilmen, Andreas, Wang, Dongli, Wang, Xinquan, Bauzon, Maxine, Kim, Ji-Yun, Linden, Lars, Li, Liang, Egner, Ursula, Marquardt, Tobias, Moosmayer, Dieter, Tebbe, Jan, Glück, Julian Marius, Ellinger, Philipp, McLean, Kirk, Yuan, Shujun, Yegneswaran, Subramanian, Jiang, Xiaoqiao, Evans, Vince, Gu, Jian-Ming, Schneider, Doug, Zhu, Ying, Xu, Yifan, Mallari, Cornell, Hesslein, Ashley, Wang, Yan, Schmidt, Nicole, Gutberlet, Katrin, Ruehl-Fehlert, Christine, Freyberger, Alexius, Hermiston, Terry, Patel, Chandra, Sim, Derek, Mosnier, Laurent O., Laux, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293249/
https://www.ncbi.nlm.nih.gov/pubmed/32532974
http://dx.doi.org/10.1038/s41467-020-16720-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293249/
https://www.ncbi.nlm.nih.gov/pubmed/32532974
http://dx.doi.org/10.1038/s41467-020-16720-9

Ejemplares similares