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Crystal structures of Uso1 membrane tether reveal an alternative conformation in the globular head domain

Membrane tethers play a critical role in organizing the complex molecular architecture of eukaryotic cells. Uso1 (yeast homolog of human p115) is essential for tethering in vesicle transport from ER to Golgi and interacts with Ypt1 GTPase. The N-terminal globular head domain of Uso1 is responsible f...

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Detalles Bibliográficos
Autores principales: Heo, Yoonyoung, Yoon, Hye-Jin, Ko, Hanseo, Jang, Soonmin, Lee, Hyung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293329/
https://www.ncbi.nlm.nih.gov/pubmed/32533038
http://dx.doi.org/10.1038/s41598-020-66480-1