Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy

We perform a CRISPR-Cas9 genome-wide screen in glioblastoma stem cells and identify integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is correlated with ZIKV susceptibility in various cells and tropism in developing human cerebral cortex. A blocking antibody agains...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shaobo, Zhang, Qiong, Tiwari, Shashi Kant, Lichinchi, Gianluigi, Yau, Edwin H., Hui, Hui, Li, Wanyu, Furnari, Frank, Rana, Tariq M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293422/
https://www.ncbi.nlm.nih.gov/pubmed/31956073
http://dx.doi.org/10.1016/j.celrep.2019.11.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293422/
https://www.ncbi.nlm.nih.gov/pubmed/31956073
http://dx.doi.org/10.1016/j.celrep.2019.11.020

Ejemplares similares