RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation

Amyloid-β protein (Aβ) is the main component of neuritic plaques, the pathological hallmark of Alzheimer's disease (AD). β-site APP cleaving enzyme 1 (BACE1) is a major β-secretase contributing to Aβ generation. β-site APP cleaving enzyme 2 (BACE2), the homolog of BACE1, is not only a θ-secreta...

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Detalles Bibliográficos
Autores principales: Qiu, Kaixin, Wang, Shuai, Wang, Xin, Wang, Fengting, Wu, Yili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293731/
https://www.ncbi.nlm.nih.gov/pubmed/32566665
http://dx.doi.org/10.1155/2020/1920789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293731/
https://www.ncbi.nlm.nih.gov/pubmed/32566665
http://dx.doi.org/10.1155/2020/1920789

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