Cargando…

Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury

OBJECTIVES: Protein kinase R-like ER kinase (PERK)/eukaryotic initiation factor 2 alpha (eIF2α) is an important factor along the main pathways for endoplasmic reticulum (ER) stress-mediated apoptosis. In this study, we investigated the effects of eIF2α phosphorylation on hepatocyte apoptosis and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Yong-Jing, Chen, Huan, Yi, Yu, Chen, Gui-Mei, Yang, Fang-Wan, Li, Ying, Tian, Ren-Dong, Huang, Wen-Ge, Cheng, Qi-Jiao, He, Yi-Huai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293739/ https://www.ncbi.nlm.nih.gov/pubmed/32566674 http://dx.doi.org/10.1155/2020/2626090

Ejemplares similares

Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells
por: Teng, Y, et al.
Publicado: (2014)

Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner
por: Yu, Chen-Lin, et al.
Publicado: (2019)

Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2α Signaling
por: Wu, Yue-Lan, et al.
Publicado: (2022)

Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis
por: Liu, Si-Ying, et al.
Publicado: (2022)

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
por: Novoa, Isabel, et al.
Publicado: (2001)

Inhibiting alpha subunit of eukaryotic initiation factor 2 dephosphorylation protects injured hepatocytes and reduces hepatocyte proliferation in acute liver injury
por: Chen, Guimei, et al.
Publicado: (2019)

GSDMD enhances cisplatin-induced apoptosis by promoting the phosphorylation of eIF2α and activating the ER-stress response
por: Zhang, Qianyu, et al.
Publicado: (2022)

Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis
por: Sequeira, Sharon J, et al.
Publicado: (2009)

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage
por: Matsuoka, Masato, et al.
Publicado: (2015)

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
por: Crespillo-Casado, Ana, et al.
Publicado: (2017)

GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis
por: Zhu, Ting, et al.
Publicado: (2021)

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant
por: Eytan, Karin, et al.
Publicado: (2022)

ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α
por: Yao, Jia, et al.
Publicado: (2022)

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway
por: Tang, Yan, et al.
Publicado: (2017)

Intracellular alpha-fetoprotein mitigates hepatocyte apoptosis and necroptosis by inhibiting endoplasmic reticulum stress
por: Chen, Yun-Fen, et al.
Publicado: (2022)

Inhibition of EIF2α Dephosphorylation Decreases Cell Viability and Synergizes with Standard-of-Care Chemotherapeutics in Head and Neck Squamous Cell Carcinoma
por: Cyran, Anna M., et al.
Publicado: (2023)

Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation
por: Sehrawat, Urmila, et al.
Publicado: (2022)

The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer
por: Chern, Yi-Jye, et al.
Publicado: (2019)

Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis
por: Tao, Yan-yan, et al.
Publicado: (2014)

Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes
por: Xu, Jiqian, et al.
Publicado: (2015)

The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition
por: Zhang, Kun, et al.
Publicado: (2019)

Reduced EGFR Level in eIF2α Phosphorylation-Deficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
por: Kim, Mi-Jeong, et al.
Publicado: (2020)

Autophagy protects against palmitate-induced apoptosis in hepatocytes
por: Cai, Ning, et al.
Publicado: (2014)

Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs
por: Bollo, Mariana, et al.
Publicado: (2010)

Mechanism of Hepatocyte Apoptosis
por: Cao, Lei, et al.
Publicado: (2016)

eIF3a‐PPP2R5A‐mediated ATM/ATR dephosphorylation is essential for irinotecan‐induced DNA damage response
por: Mei, Chao, et al.
Publicado: (2022)

Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice
por: Zhang, Yuan, et al.
Publicado: (2022)

Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes
por: Schlatter, Rebekka, et al.
Publicado: (2011)

The regulatory role of microRNA-1187 in TNF-α-mediated hepatocyte apoptosis in acute liver failure
por: YU, DONG SHAN, et al.
Publicado: (2012)

PTEN suppresses tumorigenesis by directly dephosphorylating Akt
por: Bu, Lang, et al.
Publicado: (2021)

Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER)
por: Ma, Shao, et al.
Publicado: (2015)

Protein Phosphatase-1α Interacts with and Dephosphorylates Polycystin-1
por: Parnell, Stephen C., et al.
Publicado: (2012)

Dephosphorylation of Centrins by Protein Phosphatase 2C α and β
por: Thissen, Marie-Christin, et al.
Publicado: (2009)

Short-Chain Fatty Acids Alleviate Hepatocyte Apoptosis Induced by Gut-Derived Protein-Bound Uremic Toxins
por: Deng, Mingjuan, et al.
Publicado: (2021)

Suppression of eIF2α kinases alleviates AD-related synaptic plasticity and spatial memory deficits
por: Ma, Tao, et al.
Publicado: (2013)

SET mediates TCE-induced liver cell apoptosis through dephosphorylation and upregulation of nucleolin
por: Ren, Xiaohu, et al.
Publicado: (2017)

Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits
por: Bhandari, Deepali, et al.
Publicado: (2013)

FOXA2 alleviates CCl(4)-induced liver fibrosis by protecting hepatocytes in mice
por: Wang, Wei, et al.
Publicado: (2017)

Modulation of Protein Synthesis by eIF2α Phosphorylation Protects Cell from Heat Stress-Mediated Apoptosis
por: Park, Soyoung, et al.
Publicado: (2018)

Crimean-Congo Hemorrhagic Fever Virus-Infected Hepatocytes Induce ER-Stress and Apoptosis Crosstalk
por: Rodrigues, Raquel, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n6g7qtb285j4ls2nqhg7e8k5ng