Smad2/3‐pathway ligand trap luspatercept enhances erythroid differentiation in murine β‐thalassaemia by increasing GATA‐1 availability

In β‐thalassaemia, anaemia results from ineffective erythropoiesis characterized by inhibition of late‐stage erythroid differentiation. We earlier used luspatercept and RAP‐536 protein traps for certain Smad2/3‐pathway ligands to implicate Smad2/3‐pathway overactivation in dysregulated erythroid dif...

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Detalles Bibliográficos
Autores principales: Martinez, Pedro A., Li, Robert, Ramanathan, Harish N., Bhasin, Manoj, Pearsall, R. Scott, Kumar, Ravindra, Suragani, Rajasekhar N. V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294138/
https://www.ncbi.nlm.nih.gov/pubmed/32351032
http://dx.doi.org/10.1111/jcmm.15243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294138/
https://www.ncbi.nlm.nih.gov/pubmed/32351032
http://dx.doi.org/10.1111/jcmm.15243

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