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Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity

Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated a strong association of obesity with the development of dementia. Furthermore, white matter damage is found in obese subjects and mouse model...

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Detalles Bibliográficos
Autores principales: Graham, Leah C., Kocalis, Heidi E., Soto, Ileana, Howell, Gareth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294467/
https://www.ncbi.nlm.nih.gov/pubmed/32273396
http://dx.doi.org/10.1523/ENEURO.0057-20.2020