Poly (ADP‐ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α‐synuclein degradation via transcription factor EB‐dependent autophagy in mutant α‐synucleinA53T model of Parkinson's disease

Poly (ADP‐ribose) polymerase 1 (PARP1) is a master regulator of diverse biological processes such as DNA repair, oxidative stress, and apoptosis. PARP1 can be activated by aggregated α‐synuclein, and this process in turn exacerbates toxicity of α‐synuclein. This circle is closely linked to the evolu...

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Detalles Bibliográficos
Autores principales: Mao, Kanmin, Chen, Jialong, Yu, Honglin, Li, Huihui, Ren, Yixian, Wu, Xian, Wen, Yue, Zou, Fei, Li, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294777/
https://www.ncbi.nlm.nih.gov/pubmed/32475059
http://dx.doi.org/10.1111/acel.13163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294777/
https://www.ncbi.nlm.nih.gov/pubmed/32475059
http://dx.doi.org/10.1111/acel.13163

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