Cargando…

Poly (ADP‐ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α‐synuclein degradation via transcription factor EB‐dependent autophagy in mutant α‐synucleinA53T model of Parkinson's disease

Poly (ADP‐ribose) polymerase 1 (PARP1) is a master regulator of diverse biological processes such as DNA repair, oxidative stress, and apoptosis. PARP1 can be activated by aggregated α‐synuclein, and this process in turn exacerbates toxicity of α‐synuclein. This circle is closely linked to the evolu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mao, Kanmin, Chen, Jialong, Yu, Honglin, Li, Huihui, Ren, Yixian, Wu, Xian, Wen, Yue, Zou, Fei, Li, Wenjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294777/ https://www.ncbi.nlm.nih.gov/pubmed/32475059 http://dx.doi.org/10.1111/acel.13163

Ejemplares similares

Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson’s disease
por: Chen, Jialong, et al.
Publicado: (2018)

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples
por: Puentes, Laura N., et al.
Publicado: (2021)

Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Poly (ADP-Ribose) and α–synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity
por: Lucien, Fabrice, et al.
Publicado: (2022)

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix
por: Osuagwu, Nelson, et al.
Publicado: (2019)

Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model
por: Flores-Cuadrado, Alicia, et al.
Publicado: (2019)

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
por: Gu, Xing-Long, et al.
Publicado: (2010)

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
por: Macdonald, Jennifer A., et al.
Publicado: (2021)

Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain
por: Kuan, Wei‐Li, et al.
Publicado: (2022)

α-Synuclein liquid condensates fuel fibrillar α-synuclein growth
por: Piroska, Leonard, et al.
Publicado: (2023)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration
por: Hastings, Lyndsay, et al.
Publicado: (2022)

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
por: Bridi, Jessika C, et al.
Publicado: (2021)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

α-synuclein and p53 functional interplay in physiopathological contexts
por: Alves da Costa, Cristine, et al.
Publicado: (2016)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration
por: Davis, Marie Y., et al.
Publicado: (2016)

Post-translational modifications of α-synuclein contribute to neurodegeneration in the colon of elderly individuals
por: XUAN, QI, et al.
Publicado: (2016)

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
por: Bourdenx, Mathieu, et al.
Publicado: (2015)

α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration
por: Fecchio, Chiara, et al.
Publicado: (2018)

Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease
por: Mori, Akio, et al.
Publicado: (2020)

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox
por: Simon, Christopher, et al.
Publicado: (2021)

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction
por: Dues, Dylan J., et al.
Publicado: (2023)

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction
por: Dues, Dylan J., et al.
Publicado: (2023)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model
por: Deng, Jiahui, et al.
Publicado: (2015)

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice
por: Naudet, Nicolas, et al.
Publicado: (2017)

RNA regulation by Poly(ADP-ribose) polymerases
por: Bock, Florian J., et al.
Publicado: (2015)

Mitotic functions of poly(ADP-ribose) polymerases
por: Slade, Dea
Publicado: (2019)

The Antiviral Activities of Poly-ADP-Ribose Polymerases
por: Malgras, Mathilde, et al.
Publicado: (2021)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Modulating the Amyloidogenesis of α-Synuclein
por: Sivanesam, Kalkena, et al.
Publicado: (2016)

Functionalization of α-synuclein fibrils
por: Povilonienė, Simona, et al.
Publicado: (2015)

Versatile Structures of α-Synuclein
por: Wang, Chuchu, et al.
Publicado: (2016)

The Synaptic Function of α-Synuclein
por: Burré, Jacqueline
Publicado: (2015)

Proteasome impairment by α-synuclein
por: Zondler, Lisa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3m8o2qem9trgso75k0cj03uujm