Glutathione peroxidase‐1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice

This study investigated the direct roles of hydrogen peroxide (H(2)O(2)) in kidney aging using transgenic mice overexpressing glutathione peroxidase‐1 (GPX1 TG). We demonstrated that kidneys in old mice recapitulated kidneys in elderly humans and were characterized by glomerulosclerosis, tubular atr...

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Detalles Bibliográficos
Autores principales: Chu, Yi, Lan, Renny S., Huang, Rui, Feng, Hao, Kumar, Rahul, Dayal, Sanjana, Chan, Kung‐Sik, Dai, Dao‐Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294784/
https://www.ncbi.nlm.nih.gov/pubmed/32400101
http://dx.doi.org/10.1111/acel.13154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294784/
https://www.ncbi.nlm.nih.gov/pubmed/32400101
http://dx.doi.org/10.1111/acel.13154

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