Phase and context shape the function of composite oncogenic mutations

Cancers develop as a result of driver mutations(1,2) that lead to clonal outgrowth and disease evolution(3,4). The discovery and functional characterization of individual driver mutations is a central aim of cancer research and has elucidated myriad phenotypes(5) and therapeutic vulnerabilities(6)....

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Detalles Bibliográficos
Autores principales: Gorelick, Alexander N., Sánchez-Rivera, Francisco J., Cai, Yanyan, Bielski, Craig M., Biederstedt, Evan, Jonsson, Philip, Richards, Allison L., Vasan, Neil, Penson, Alexander V., Friedman, Noah D., Ho, Yu-Jui, Baslan, Timour, Bandlamudi, Chaitanya, Scaltriti, Maurizio, Schultz, Nikolaus, Lowe, Scott W., Reznik, Ed, Taylor, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294994/
https://www.ncbi.nlm.nih.gov/pubmed/32461694
http://dx.doi.org/10.1038/s41586-020-2315-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294994/
https://www.ncbi.nlm.nih.gov/pubmed/32461694
http://dx.doi.org/10.1038/s41586-020-2315-8

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