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Phase and context shape the function of composite oncogenic mutations
Cancers develop as a result of driver mutations(1,2) that lead to clonal outgrowth and disease evolution(3,4). The discovery and functional characterization of individual driver mutations is a central aim of cancer research and has elucidated myriad phenotypes(5) and therapeutic vulnerabilities(6)....
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294994/ https://www.ncbi.nlm.nih.gov/pubmed/32461694 http://dx.doi.org/10.1038/s41586-020-2315-8 |