Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade

Rationale: Wear particle-induced periprosthetic osteolysis (PPO) is a common long-term complication of total joint arthroplasty, and represents the major cause of aseptic loosening and subsequent implant failure. Previous studies have identified the central role of osteoclast-mediated bone resorptio...

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Detalles Bibliográficos
Autores principales: Zhang, Liwei, Yang, Yanjun, Liao, Zirui, Liu, Qingbai, Lei, Xinhuan, Li, Meng, Saijilafu, Zhang, Zunyi, Hong, Dun, Zhu, Min, Li, Bin, Yang, Huilin, Chen, Jianquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295048/
https://www.ncbi.nlm.nih.gov/pubmed/32550895
http://dx.doi.org/10.7150/thno.44793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295048/
https://www.ncbi.nlm.nih.gov/pubmed/32550895
http://dx.doi.org/10.7150/thno.44793

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