Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease

Repeated failures of “Aβ-lowering” therapies call for new targets and therapeutic approaches for Alzheimer's disease (AD). We propose to treat AD by halting neuronal death and repairing synapses using a BDNF-based therapy. To overcome the poor druggability of BDNF, we have developed an agonisti...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shudan, Yao, Hongyang, Xu, Yihua, Hao, Rui, Zhang, Wen, Liu, Hang, Huang, Ying, Guo, Wei, Lu, Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295064/
https://www.ncbi.nlm.nih.gov/pubmed/32550908
http://dx.doi.org/10.7150/thno.44165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295064/
https://www.ncbi.nlm.nih.gov/pubmed/32550908
http://dx.doi.org/10.7150/thno.44165

Ejemplares similares