Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured microvascular endothelial cells, Piezo1 channel activat...

Descripción completa

Detalles Bibliográficos
Autores principales: Caolo, Vincenza, Debant, Marjolaine, Endesh, Naima, Futers, T Simon, Lichtenstein, Laeticia, Bartoli, Fiona, Parsonage, Gregory, Jones, Elizabeth AV, Beech, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295575/
https://www.ncbi.nlm.nih.gov/pubmed/32484440
http://dx.doi.org/10.7554/eLife.50684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295575/
https://www.ncbi.nlm.nih.gov/pubmed/32484440
http://dx.doi.org/10.7554/eLife.50684

Ejemplares similares