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Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured microvascular endothelial cells, Piezo1 channel activat...
Autores principales: | Caolo, Vincenza, Debant, Marjolaine, Endesh, Naima, Futers, T Simon, Lichtenstein, Laeticia, Bartoli, Fiona, Parsonage, Gregory, Jones, Elizabeth AV, Beech, David J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295575/ https://www.ncbi.nlm.nih.gov/pubmed/32484440 http://dx.doi.org/10.7554/eLife.50684 |
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