Hyperpolarized [1,4-(13)C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy

Today, there is a general lack of prognostic biomarkers for development of renal disease and in particular diabetic nephropathy. Increased glycolytic activity, lactate accumulation and altered mitochondrial oxygen utilization are hallmarks of diabetic kidney disease. Fumarate hydratase activity has...

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Detalles Bibliográficos
Autores principales: Laustsen, Christoffer, Nielsen, Per Mose, Qi, Haiyun, Løbner, Mette Hadberg, Palmfeldt, Johan, Bertelsen, Lotte Bonde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295762/
https://www.ncbi.nlm.nih.gov/pubmed/32541797
http://dx.doi.org/10.1038/s41598-020-66265-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295762/
https://www.ncbi.nlm.nih.gov/pubmed/32541797
http://dx.doi.org/10.1038/s41598-020-66265-6

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