Cargando…

α-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells

The presence of α-synuclein aggregates in the retina of Parkinson’s disease patients has been associated with vision impairment. In this study we sought to determine the effects of α-synuclein overexpression on the survival and function of dopaminergic amacrine cells (DACs) in the retina. Adult mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marrocco, Elena, Indrieri, Alessia, Esposito, Federica, Tarallo, Valeria, Carboncino, Anna, Alvino, Filomena Grazia, De Falco, Sandro, Franco, Brunella, De Risi, Maria, De Leonibus, Elvira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295803/ https://www.ncbi.nlm.nih.gov/pubmed/32541823 http://dx.doi.org/10.1038/s41598-020-66497-6

Ejemplares similares

Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
por: Indrieri, Alessia, et al.
Publicado: (2020)

Reexamination of Dopaminergic Amacrine Cells in the Rabbit Retina: Confocal Analysis with Double- and Triple-labeling Immunohistochemistry
por: Lee, Jong Woo, et al.
Publicado: (2017)

Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina
por: Zhao, Xiwu, et al.
Publicado: (2017)

Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina
por: Liu, Lei-Lei, et al.
Publicado: (2019)

Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina
por: Pérez de Sevilla Müller, Luis, et al.
Publicado: (2017)

Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina
por: Jo, Andrew, et al.
Publicado: (2018)

Light-dependent pathways for dopaminergic amacrine cell development and function
por: Munteanu, Teona, et al.
Publicado: (2018)

Analysis of synaptic inputs to on-off amacrine cells of the carp retina
Publicado: (1988)

Functional Compartmentalization within Starburst Amacrine Cell Dendrites in the Retina
por: Poleg-Polsky, Alon, et al.
Publicado: (2018)

Ganglion cells and displaced amacrine cells density in the retina of the collared peccary (Pecari tajacu)
por: Costa, Kelly Helorany Alves, et al.
Publicado: (2020)

Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina
por: Dudczig, Stefanie, et al.
Publicado: (2017)

Ganglion Cell and Displaced Amacrine Cell Density Distribution in the Retina of the Howler Monkey (Alouatta caraya)
por: Muniz, José Augusto Pereira Carneiro, et al.
Publicado: (2014)

Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
por: Sánchez-Sáez, Xavier, et al.
Publicado: (2023)

AII amacrine cells in the primate fovea contribute to photopic vision
por: Strettoi, Enrica, et al.
Publicado: (2018)

Lgr5(+) amacrine cells possess regenerative potential in the retina of adult mice
por: Chen, Mengfei, et al.
Publicado: (2015)

Correction: Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
por: Sánchez‑Sáez, Xavier, et al.
Publicado: (2023)

Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling
por: Hu, Songhui, et al.
Publicado: (2022)

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
por: De Risi, Maria, et al.
Publicado: (2021)

AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease
por: Gatto, Francesca, et al.
Publicado: (2017)

Muscarinic signaling influences the patterning and phenotype of cholinergic amacrine cells in the developing chick retina
por: Stanke, Jennifer J, et al.
Publicado: (2008)

Loss of LMO4 in the Retina Leads to Reduction of GABAergic Amacrine Cells and Functional Deficits
por: Duquette, Philippe M., et al.
Publicado: (2010)

Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina
por: Ivanova, Elena, et al.
Publicado: (2015)

AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells
por: Jain, Saket, et al.
Publicado: (2018)

Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina
por: Banerjee, Seema, et al.
Publicado: (2020)

Off Starburst Amacrine Cells in the Retina Trigger Looming-Evoked Fear Responses in Mice
por: Bohl, Jeremy M., et al.
Publicado: (2023)

Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina
por: Maruyama, Takuma, et al.
Publicado: (2023)

Optogenetic targeting of AII amacrine cells restores retinal computations performed by the inner retina
por: Khabou, Hanen, et al.
Publicado: (2023)

Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice
por: Peoples, Cassandra, et al.
Publicado: (2012)

Vulnerability of Dopaminergic Amacrine Cells to Chronic Ischemia in a Mouse Model of Oxygen-Induced Retinopathy
por: Spix, Nathan J., et al.
Publicado: (2016)

Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina
por: Jusuf, Patricia R, et al.
Publicado: (2009)

Response Properties of a Newly Identified Tristratified Narrow Field Amacrine Cell in the Mouse Retina
por: Newkirk, G. S., et al.
Publicado: (2015)

The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution
por: Liu, Jian Hao, et al.
Publicado: (2022)

Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors
por: Qiao, Sheng-Nan, et al.
Publicado: (2017)

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells
por: Liu, Lei-Lei, et al.
Publicado: (2017)

miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases
por: Carrella, Sabrina, et al.
Publicado: (2022)

Seizure-Related Gene 6 (Sez-6) in Amacrine Cells of the Rodent Retina and the Consequence of Gene Deletion
por: Gunnersen, Jenny M., et al.
Publicado: (2009)

Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque monkey retina
por: Manookin, Michael B., et al.
Publicado: (2015)

Early Microvascular and Oscillatory Potentials Changes in Human Diabetic Retina: Amacrine Cells and the Intraretinal Neurovascular Crosstalk
por: Midena, Edoardo, et al.
Publicado: (2021)

Quantitative trait loci on chromosomes 9 and 19 modulate AII amacrine cell number in the mouse retina
por: Kulesh, Bridget, et al.
Publicado: (2023)

Calcium-permeable AMPA receptors on AII amacrine cells mediate sustained signaling in the On-pathway of the primate retina
por: Percival, Kumiko A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9q6mq7l3p4dhbskgrltr660cuk