Gene-signature-derived IC(50)s/EC(50)s reflect the potency of causative upstream targets and downstream phenotypes

Multiplexed gene-signature-based phenotypic assays are increasingly used for the identification and profiling of small molecule-tool compounds and drugs. Here we introduce a method (provided as R-package) for the quantification of the dose-response potency of a gene-signature as EC(50) and IC(50) va...

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Detalles Bibliográficos
Autores principales: Renner, Steffen, Bergsdorf, Christian, Bouhelal, Rochdi, Koziczak-Holbro, Magdalena, Amati, Andrea Marco, Techer-Etienne, Valerie, Flotte, Ludivine, Reymann, Nicole, Kapur, Karen, Hoersch, Sebastian, Oakeley, Edward James, Schuffenhauer, Ansgar, Gubler, Hanspeter, Lounkine, Eugen, Farmer, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295968/
https://www.ncbi.nlm.nih.gov/pubmed/32541899
http://dx.doi.org/10.1038/s41598-020-66533-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295968/
https://www.ncbi.nlm.nih.gov/pubmed/32541899
http://dx.doi.org/10.1038/s41598-020-66533-5

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