Cargando…

Gene-signature-derived IC(50)s/EC(50)s reflect the potency of causative upstream targets and downstream phenotypes

Multiplexed gene-signature-based phenotypic assays are increasingly used for the identification and profiling of small molecule-tool compounds and drugs. Here we introduce a method (provided as R-package) for the quantification of the dose-response potency of a gene-signature as EC(50) and IC(50) va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Renner, Steffen, Bergsdorf, Christian, Bouhelal, Rochdi, Koziczak-Holbro, Magdalena, Amati, Andrea Marco, Techer-Etienne, Valerie, Flotte, Ludivine, Reymann, Nicole, Kapur, Karen, Hoersch, Sebastian, Oakeley, Edward James, Schuffenhauer, Ansgar, Gubler, Hanspeter, Lounkine, Eugen, Farmer, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295968/ https://www.ncbi.nlm.nih.gov/pubmed/32541899 http://dx.doi.org/10.1038/s41598-020-66533-5

Ejemplares similares

EC(50) and EC(95) of remifentanil to prevent rocuronium-induced withdrawal movements in children
por: Park, Hye Jin, et al.
Publicado: (2014)

Variations in IC(50) Values with Purity of Mushroom Tyrosinase
por: Neeley, Elizabeth, et al.
Publicado: (2009)

Proteochemometric Method for pIC50 Prediction of Flaviviridae
por: Singh, Divye, et al.
Publicado: (2022)

IC(50)-to-K(i): a web-based tool for converting IC(50) to K(i) values for inhibitors of enzyme activity and ligand binding
por: Cer, R. Z., et al.
Publicado: (2009)

Comparability of Mixed IC(50) Data – A Statistical Analysis
por: Kalliokoski, Tuomo, et al.
Publicado: (2013)

Evidence for an effect of receptor density on ligand occupancy and agonist EC(50)
por: Jarvis, Gavin E., et al.
Publicado: (2019)

Predicted EC(50) and EC(95) of Remifentanil for Smooth Removal of a Laryngeal Mask Airway Under Propofol Anesthesia
por: Yoo, Ji Young, et al.
Publicado: (2015)

The combined effect of Bassa 50EC and Vitashield 40EC on the brain acetylcholinesterase activity in climbing perch (Anabas testudineus)
por: Tam, Nguyen Thanh, et al.
Publicado: (2018)

Beyond IC(50)s: Towards Robust Statistical Methods for in vitro Association Studies
por: Beam, Andrew, et al.
Publicado: (2014)

A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC(50)
por: Zhang, Hui, et al.
Publicado: (2013)

When Does the IC(50) Accurately Assess the Blocking Potency of a Drug?
por: Gomis-Tena, Julio, et al.
Publicado: (2020)

The influence of age and gender on remifentanil EC(50) for preventing rocuronium induced withdrawal movements
por: Park, So Jin, et al.
Publicado: (2010)

The effect of gender on EC(50) of remifentanil to prevent pain during injection of microemulsion propofol
por: Lee, Bo-Won, et al.
Publicado: (2012)

The EC(50) of remifentanil to minimize the cardiovascular changes during head holder pinning in neurosurgery
por: Do, Wang Seok, et al.
Publicado: (2012)

Sufentanil EC50 for endotracheal intubation with aerosol inhalation of carbonated lidocaine by ultrasonic atomizer
por: Xu, Qiaoqiao, et al.
Publicado: (2021)

Predicting the DPP-IV Inhibitory Activity pIC(50) Based on Their Physicochemical Properties
por: Gu, Tianhong, et al.
Publicado: (2013)

Comparative Study on the EC(50) Value in Single and Mixtures of Dimethylformamide, Methyl Ethyl Ketone, and Toluene
por: Kim, Ki-Woong, et al.
Publicado: (2014)

Adjuvant Sufentanil Decreased the EC50 of Epidural Ropivacaine for Labor Analgesia in Healthy Term Pregnancy
por: Xiang, Bo, et al.
Publicado: (2021)

Terpenes Increase the Lipid Dynamics in the Leishmania Plasma Membrane at Concentrations Similar to Their IC(50) Values
por: Camargos, Heverton Silva, et al.
Publicado: (2014)

IC(50): an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
por: Xu, Yipeng, et al.
Publicado: (2022)

On Approximating the pIC(50) Value of COVID-19 Medicines In Silico with Artificial Neural Networks
por: Baressi Šegota, Sandi, et al.
Publicado: (2023)

Cutoff value of IC(50) for drug sensitivity in patient-derived tumor organoids in colorectal cancer
por: Tang, Yuting, et al.
Publicado: (2023)

The changing 50% inhibitory concentration (IC(50)) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer
por: He, Yifeng, et al.
Publicado: (2016)

The median effective concentration (EC50) of propofol with different doses of fentanyl during colonoscopy in elderly patients
por: Li, Shiyang, et al.
Publicado: (2016)

Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction
por: Lee, Yeeun, et al.
Publicado: (2021)

Corrigendum: IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
Publicado: (2023)

EC-IC bypass for cavernous carotid aneurysms: An initial experience with twelve patients
por: Menon, G., et al.
Publicado: (2014)

Effect of transcutaneous electrical acupoint stimulation on the EC(50) of remifentanil suppressing responses to tracheal extubation in elderly patients
por: Yin, Chun-Ping, et al.
Publicado: (2018)

Dexmedetomidine reduces sevoflurane EC(50) for supraglottic airway device insertion in spontaneously breathing morbidly obese patients
por: Wan, Lei, et al.
Publicado: (2019)

Ecotoxicological Risk Assessment of Actellic 50 EC Insecticide on Non-Target Organisms in Parallel with the Application of Standardized Tests
por: Paunescu, Alina, et al.
Publicado: (2022)

Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism
por: Bridges, James P, et al.
Publicado: (2022)

Effect of Inducers, Incubation Time and Heme Concentration on IC(50) Value Variation in Anti-heme Crystallization Assay
por: Nhien, Nguyen Thanh Thuy, et al.
Publicado: (2011)

A novel application of t-statistics to objectively assess the quality of IC(50) fits for P-glycoprotein and other transporters
por: O'Connor, Michael, et al.
Publicado: (2015)

IC(50) Evaluation of Platinum Nanocatalysts for Cancer Treatment in Fibroblast, HeLa, and DU-145 Cell Lines
por: González-Larraza, Pamela G., et al.
Publicado: (2020)

Numerical learning of deep features from drug-exposed cell images to calculate IC50 without staining
por: Cho, Kookrae, et al.
Publicado: (2022)

The Median Effective Concentration (EC(50)) of Epidural Ropivacaine With Different Doses of Oxycodone During Limb Surgery in Elderly Patients
por: Xie, Kai, et al.
Publicado: (2022)

4D-flow assessment of cerebral hemodynamic in patients with post EC-IC bypass
por: Sekine, Tetsuro, et al.
Publicado: (2012)

The role of EC-IC bypass in ICA blood blister aneurysms—a systematic review
por: Meling, Torstein R., et al.
Publicado: (2020)

Comparison of Quantitative and Qualitative (Q)SAR Models Created for the Prediction of K(i) and IC(50) Values of Antitarget Inhibitors
por: Lagunin, Alexey A., et al.
Publicado: (2018)

A Deep Learning Model for Cell Growth Inhibition IC50 Prediction and Its Application for Gastric Cancer Patients
por: Joo, Minjae, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oh5f6a750v66pn6h9ideb7qarn