Abrogation of PRRSV infectivity by CRISPR-Cas13b-mediated viral RNA cleavage in mammalian cells

CRISPR/Cas9 enables dsDNA viral genome engineering. However, the lack of RNA targeting activities limits the ability of CRISPR/Cas9 to combat RNA viruses. The recently identified class II type VI CRISPR/Cas effectors (Cas13) are RNA-targeting CRISPR enzymes that enable RNA cleavage in mammalian and...

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Detalles Bibliográficos
Autores principales: Cui, Jin, Techakriengkrai, Navapon, Nedumpun, Teerawut, Suradhat, Sanipa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295971/
https://www.ncbi.nlm.nih.gov/pubmed/32541822
http://dx.doi.org/10.1038/s41598-020-66775-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295971/
https://www.ncbi.nlm.nih.gov/pubmed/32541822
http://dx.doi.org/10.1038/s41598-020-66775-3

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