Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimerʼs disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises...

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Detalles Bibliográficos
Autores principales: Ciudad, Sonia, Puig, Eduard, Botzanowski, Thomas, Meigooni, Moeen, Arango, Andres S., Do, Jimmy, Mayzel, Maxim, Bayoumi, Mariam, Chaignepain, Stéphane, Maglia, Giovanni, Cianferani, Sarah, Orekhov, Vladislav, Tajkhorshid, Emad, Bardiaux, Benjamin, Carulla, Natàlia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296003/
https://www.ncbi.nlm.nih.gov/pubmed/32541820
http://dx.doi.org/10.1038/s41467-020-16566-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296003/
https://www.ncbi.nlm.nih.gov/pubmed/32541820
http://dx.doi.org/10.1038/s41467-020-16566-1

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