Mitochondrial dysfunction generates aggregates that resist lysosomal degradation in human breast cancer cells

Disrupting functional protein homeostasis is an established therapeutic strategy for certain tumors. Ongoing studies are evaluating autophagy inhibition for overcoming chemotherapeutic resistance to such therapies by neutralizing lysosomal pH. New and sensitive methods to monitor autophagy in patien...

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Detalles Bibliográficos
Autores principales: Biel, Thomas G., Aryal, Baikuntha, Gerber, Michael H., Trevino, Josè G., Mizuno, Naoko, Rao, V. Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296005/
https://www.ncbi.nlm.nih.gov/pubmed/32541677
http://dx.doi.org/10.1038/s41419-020-2658-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296005/
https://www.ncbi.nlm.nih.gov/pubmed/32541677
http://dx.doi.org/10.1038/s41419-020-2658-y

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