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Mitochondrial dysfunction generates aggregates that resist lysosomal degradation in human breast cancer cells
Disrupting functional protein homeostasis is an established therapeutic strategy for certain tumors. Ongoing studies are evaluating autophagy inhibition for overcoming chemotherapeutic resistance to such therapies by neutralizing lysosomal pH. New and sensitive methods to monitor autophagy in patien...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296005/ https://www.ncbi.nlm.nih.gov/pubmed/32541677 http://dx.doi.org/10.1038/s41419-020-2658-y |