Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

BACKGROUND/AIM: Hypertensive cardiac hypertrophy is the leading cause of cardiac remodeling and heart failure. We recently demonstrated that the immunoproteasome, an inducible form of the constitutive proteasome, plays a critical role in regulating cardiovascular diseases. However, the role of the i...

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Detalles Bibliográficos
Autores principales: Yan, Wen, Dong, Zhi-Chao, Wang, Jing-Jing, Zhang, Yun-Long, Wang, Hong-Xia, Zhang, Bo, Li, Hui-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296172/
https://www.ncbi.nlm.nih.gov/pubmed/32581853
http://dx.doi.org/10.3389/fphys.2020.00625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296172/
https://www.ncbi.nlm.nih.gov/pubmed/32581853
http://dx.doi.org/10.3389/fphys.2020.00625

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