Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice

FcgRIIB dysfunction is commonly found in patients with lupus, especially in Asia. LPS-tolerance is prominent in FcgRIIB–/– lupus mice. LPS-tolerant macrophages demonstrate cell energy depletion, which might affect lipid metabolism. Therefore, to explore lipid metabolism, LPS-tolerance was induced tw...

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Detalles Bibliográficos
Autores principales: Jaroonwitchawan, Thiranut, Visitchanakun, Peerapat, Dang, Phi Cong, Ritprajak, Patcharee, Palaga, Tanapat, Leelahavanichkul, Asada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296175/
https://www.ncbi.nlm.nih.gov/pubmed/32582149
http://dx.doi.org/10.3389/fimmu.2020.00959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296175/
https://www.ncbi.nlm.nih.gov/pubmed/32582149
http://dx.doi.org/10.3389/fimmu.2020.00959

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