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FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells

BACKGROUND: Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, and hyperproliferation of cells is a major problem of OS. FBXO2 belongs to the family of F-box proteins, and is a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin li...

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Detalles Bibliográficos
Autores principales: Zhao, Xunming, Guo, Weichun, Zou, Lixue, Hu, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296666/
https://www.ncbi.nlm.nih.gov/pubmed/32549792
http://dx.doi.org/10.1186/s12935-020-01326-4