Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression

Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of action as an antidepressant, are still unclear. We investigated ketamine’s effect...

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Detalles Bibliográficos
Autores principales: Aleksandrova, Lily R., Wang, Yu Tian, Phillips, Anthony G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296711/
https://www.ncbi.nlm.nih.gov/pubmed/32546197
http://dx.doi.org/10.1186/s13041-020-00627-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296711/
https://www.ncbi.nlm.nih.gov/pubmed/32546197
http://dx.doi.org/10.1186/s13041-020-00627-z

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