Cargando…

Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression

Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of action as an antidepressant, are still unclear. We investigated ketamine’s effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aleksandrova, Lily R., Wang, Yu Tian, Phillips, Anthony G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296711/ https://www.ncbi.nlm.nih.gov/pubmed/32546197 http://dx.doi.org/10.1186/s13041-020-00627-z

Ejemplares similares

Ketamine promptly normalizes excess norepinephrine and enhances dopamine neuronal activity in Wistar Kyoto rats
por: Daniels, Stephen, et al.
Publicado: (2023)

The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression
por: McDonnell, Conor W., et al.
Publicado: (2021)

Aging Impairs Hippocampal- Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation
por: Arias-Cavieres, Alejandra, et al.
Publicado: (2017)

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
por: Ayala, Jennifer E., et al.
Publicado: (2009)

Learned helplessness and social avoidance in the Wistar-Kyoto rat
por: Nam, Hyungwoo, et al.
Publicado: (2014)

Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats
por: HAMADA, Mizuki, et al.
Publicado: (2019)

Strain differences in baroceptor reflex in adult wistar kyoto rats
por: Valenti, Vitor E., et al.
Publicado: (2010)

Gastroparesis and lipid metabolism-associated dysbiosis in Wistar-Kyoto rats
por: Dalziel, J. E., et al.
Publicado: (2017)

Recognition Memory Induces Natural LTP-like Hippocampal Synaptic Excitation and Inhibition
por: Sánchez-Rodríguez, Irene, et al.
Publicado: (2022)

Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP
por: Belardo, Carmela, et al.
Publicado: (2023)

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action
por: Aleksandrova, Lily R., et al.
Publicado: (2017)

Dysfunctional Inhibitory Mechanisms in Locus Coeruleus Neurons of the Wistar Kyoto Rat
por: Bruzos-Cidón, C, et al.
Publicado: (2015)

Wistar-Kyoto Female Rats Are More Susceptible to Develop Sugar Binging: A Comparison with Wistar Rats
por: Papacostas-Quintanilla, Helena, et al.
Publicado: (2017)

Proteins Binding to the Carbohydrate HNK-1: Common Origins?
por: Castillo, Gaston, et al.
Publicado: (2021)

The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats
por: Moaddel, Ruin, et al.
Publicado: (2015)

Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)
por: Herzog, David P., et al.
Publicado: (2021)

The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model
por: Liu, An-Ran, et al.
Publicado: (2023)

Long-Term Heavy Ketamine Use is Associated with Spatial Memory Impairment and Altered Hippocampal Activation
por: Morgan, Celia J. A., et al.
Publicado: (2014)

Patterns of motor activity in spontaneously hypertensive rats compared to Wistar Kyoto rats
por: Fasmer, Ole Bernt, et al.
Publicado: (2016)

Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats
por: Bayles, Richard G., et al.
Publicado: (2019)

Sex-Specific Behavioral Response to Early Adolescent Stress in the Genetically More Stress-Reactive Wistar Kyoto More Immobile, and Its Nearly Isogenic Wistar Kyoto Less Immobile Control Strain
por: Kim, Sarah, et al.
Publicado: (2021)

HNK-1 antibody detects an antigen expressed on neuroectodermal cells
Publicado: (1983)

Functions of Small Organic Compounds that Mimic the HNK-1 Glycan
por: Wang, Minjuan, et al.
Publicado: (2020)

Effects of Selective iNOS Inhibitor on Spatial Memory in Recovered and Non-recovered Ketamine Induced-anesthesia in Wistar Rats
por: Tabrizian, Kaveh, et al.
Publicado: (2010)

Ketamine evoked disruption of entorhinal and hippocampal spatial maps
por: Masuda, Francis Kei, et al.
Publicado: (2023)

Ketamine evoked disruption of entorhinal and hippocampal spatial maps
por: Masuda, Francis Kei, et al.
Publicado: (2023)

Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling
por: Song, Dong, et al.
Publicado: (2014)

(2S,6S)- and (2R,6R)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice
por: Kang, Heather, et al.
Publicado: (2020)

Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior
por: Herrero-Labrador, Raquel, et al.
Publicado: (2023)

Multi-input Synapses, but Not LTP-Strengthened Synapses, Correlate with Hippocampal Memory Storage in Aged Mice
por: Aziz, Wajeeha, et al.
Publicado: (2019)

Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice
por: Guo, Fangli, et al.
Publicado: (2017)

Long-Term Recording of LTP in Cultured Hippocampal Slices
por: Shimono, Ken, et al.
Publicado: (2002)

Δ(9)-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic Wistar-Kyoto Rats
por: Vella, Rebecca K., et al.
Publicado: (2017)

Late gestational exposure to dexamethasone and fetal programming of abnormal behavior in Wistar Kyoto rats
por: Lalonde, Christine, et al.
Publicado: (2021)

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats
por: Zhang, Yu, et al.
Publicado: (2021)

Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats
por: Korlatowicz, Agata, et al.
Publicado: (2022)

Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors
por: Joseph, Thomas T., et al.
Publicado: (2021)

Engineering a memory with LTD and LTP
por: Nabavi, Sadegh, et al.
Publicado: (2014)

Tissue-Specific Regulation of HNK-1 Biosynthesis by Bisecting GlcNAc
por: Kawade, Haruka, et al.
Publicado: (2021)

Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation
por: Shimshek, Derya R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_omsd56pjvhkd3kkrsdvmifmgv6