Sulfonated inhibitors of the RNA editing ligases validate the essential role of the MRP1/2 proteins in kinetoplastid RNA editing

The RNA editing core complex (RECC) catalyzes mitochondrial U-insertion/deletion mRNA editing in trypanosomatid flagellates. Some naphthalene-based sulfonated compounds, such as C35 and MrB, competitively inhibit the auto-adenylylation activity of an essential RECC enzyme, kinetoplastid RNA editing...

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Detalles Bibliográficos
Autores principales: Mehta, Vaibhav, Moshiri, Houtan, Srikanth, Akshaya, Kala, Smriti, Lukeš, Julius, Salavati, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297121/
https://www.ncbi.nlm.nih.gov/pubmed/32276989
http://dx.doi.org/10.1261/rna.075598.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297121/
https://www.ncbi.nlm.nih.gov/pubmed/32276989
http://dx.doi.org/10.1261/rna.075598.120

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