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Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins

ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions...

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Detalles Bibliográficos
Autores principales: Swaim, Caleb D., Canadeo, Larissa A., Monte, Kristen J., Khanna, Swati, Lenschow, Deborah J., Huibregtse, Jon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297157/
https://www.ncbi.nlm.nih.gov/pubmed/32553163
http://dx.doi.org/10.1016/j.celrep.2020.107772