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Discriminating between negative cooperativity and ligand binding to independent sites using pre-equilibrium properties of binding curves
Negative cooperativity is a phenomenon in which the binding of a first ligand or substrate molecule decreases the rate of subsequent binding. This definition is not exclusive to ligand-receptor binding, it holds whenever two or more molecules undergo two successive binding events. Negative cooperati...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297384/ https://www.ncbi.nlm.nih.gov/pubmed/32497065 http://dx.doi.org/10.1371/journal.pcbi.1007929 |