MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibito...

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Detalles Bibliográficos
Autores principales: Arai, Seiji, Varkaris, Andreas, Nouri, Mannan, Chen, Sen, Xie, Lisha, Balk, Steven P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297531/
https://www.ncbi.nlm.nih.gov/pubmed/32484436
http://dx.doi.org/10.7554/eLife.54954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297531/
https://www.ncbi.nlm.nih.gov/pubmed/32484436
http://dx.doi.org/10.7554/eLife.54954

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