Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

Emerging evidence supports the hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell to cell through the brain in a manner akin to infectious prions. Here, we show that mutant huntingtin (mHtt) aggregates associated with Huntington disease transfer...

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Detalles Bibliográficos
Autores principales: Donnelly, Kirby M, DeLorenzo, Olivia R, Zaya, Aprem DA, Pisano, Gabrielle E, Thu, Wint M, Luo, Liqun, Kopito, Ron R, Panning Pearce, Margaret M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297539/
https://www.ncbi.nlm.nih.gov/pubmed/32463364
http://dx.doi.org/10.7554/eLife.58499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297539/
https://www.ncbi.nlm.nih.gov/pubmed/32463364
http://dx.doi.org/10.7554/eLife.58499

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