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Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses
Emerging evidence supports the hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell to cell through the brain in a manner akin to infectious prions. Here, we show that mutant huntingtin (mHtt) aggregates associated with Huntington disease transfer...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297539/ https://www.ncbi.nlm.nih.gov/pubmed/32463364 http://dx.doi.org/10.7554/eLife.58499 |