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Predictable properties of fitness landscapes induced by adaptational tradeoffs

Fitness effects of mutations depend on environmental parameters. For example, mutations that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation to environmental extremes. We develop a mathemati...

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Autores principales: Das, Suman G, Direito, Susana OL, Waclaw, Bartlomiej, Allen, Rosalind J, Krug, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297540/
https://www.ncbi.nlm.nih.gov/pubmed/32423531
http://dx.doi.org/10.7554/eLife.55155
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author Das, Suman G
Direito, Susana OL
Waclaw, Bartlomiej
Allen, Rosalind J
Krug, Joachim
author_facet Das, Suman G
Direito, Susana OL
Waclaw, Bartlomiej
Allen, Rosalind J
Krug, Joachim
author_sort Das, Suman G
collection PubMed
description Fitness effects of mutations depend on environmental parameters. For example, mutations that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation to environmental extremes. We develop a mathematical model for fitness landscapes generated by such tradeoffs, based on experiments that determine the antibiotic dose-response curves of Escherichia coli strains, and previous observations on antibiotic resistance mutations. Our model generates a succession of landscapes with predictable properties as antibiotic concentration is varied. The landscape is nearly smooth at low and high concentrations, but the tradeoff induces a high ruggedness at intermediate antibiotic concentrations. Despite this high ruggedness, however, all the fitness maxima in the landscapes are evolutionarily accessible from the wild type. This implies that selection for antibiotic resistance in multiple mutational steps is relatively facile despite the complexity of the underlying landscape.
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spelling pubmed-72975402020-06-18 Predictable properties of fitness landscapes induced by adaptational tradeoffs Das, Suman G Direito, Susana OL Waclaw, Bartlomiej Allen, Rosalind J Krug, Joachim eLife Computational and Systems Biology Fitness effects of mutations depend on environmental parameters. For example, mutations that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation to environmental extremes. We develop a mathematical model for fitness landscapes generated by such tradeoffs, based on experiments that determine the antibiotic dose-response curves of Escherichia coli strains, and previous observations on antibiotic resistance mutations. Our model generates a succession of landscapes with predictable properties as antibiotic concentration is varied. The landscape is nearly smooth at low and high concentrations, but the tradeoff induces a high ruggedness at intermediate antibiotic concentrations. Despite this high ruggedness, however, all the fitness maxima in the landscapes are evolutionarily accessible from the wild type. This implies that selection for antibiotic resistance in multiple mutational steps is relatively facile despite the complexity of the underlying landscape. eLife Sciences Publications, Ltd 2020-05-19 /pmc/articles/PMC7297540/ /pubmed/32423531 http://dx.doi.org/10.7554/eLife.55155 Text en © 2020, Das et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Das, Suman G
Direito, Susana OL
Waclaw, Bartlomiej
Allen, Rosalind J
Krug, Joachim
Predictable properties of fitness landscapes induced by adaptational tradeoffs
title Predictable properties of fitness landscapes induced by adaptational tradeoffs
title_full Predictable properties of fitness landscapes induced by adaptational tradeoffs
title_fullStr Predictable properties of fitness landscapes induced by adaptational tradeoffs
title_full_unstemmed Predictable properties of fitness landscapes induced by adaptational tradeoffs
title_short Predictable properties of fitness landscapes induced by adaptational tradeoffs
title_sort predictable properties of fitness landscapes induced by adaptational tradeoffs
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297540/
https://www.ncbi.nlm.nih.gov/pubmed/32423531
http://dx.doi.org/10.7554/eLife.55155
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