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High-throughput interrogation of programmed ribosomal frameshifting in human cells

Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human viruses such as HIV and SARS coronavirus and is critical for their replication. Here, we developed a high-throughput approach to assess th...

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Detalles Bibliográficos
Autores principales: Mikl, Martin, Pilpel, Yitzhak, Segal, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297798/
https://www.ncbi.nlm.nih.gov/pubmed/32546731
http://dx.doi.org/10.1038/s41467-020-16961-8