Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502...

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Detalles Bibliográficos
Autores principales: Lie, Maria E. K., Kickinger, Stefanie, Skovgaard-Petersen, Jonas, Ecker, Gerhard F., Clausen, Rasmus P., Schousboe, Arne, White, H. Steve, Wellendorph, Petrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297817/
https://www.ncbi.nlm.nih.gov/pubmed/32248400
http://dx.doi.org/10.1007/s11064-020-03017-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297817/
https://www.ncbi.nlm.nih.gov/pubmed/32248400
http://dx.doi.org/10.1007/s11064-020-03017-y

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