Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke

ABSTRACT: Transforming growth factor-β-activated kinase 1 (TAK1) is upregulated after cerebral ischemia and contributes to an aggravation of brain injury. TAK1 acts as a key regulator of NF-ΚB and the MAP kinases JNK and p38 and modulates post-ischemic neuroinflammation and apoptosis. Microglia are...

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Detalles Bibliográficos
Autores principales: Zeyen, Thomas, Noristani, Rozina, Habib, Shahin, Heinisch, Ole, Slowik, Alexander, Huber, Michael, Schulz, Jörg B., Reich, Arno, Habib, Pardes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297861/
https://www.ncbi.nlm.nih.gov/pubmed/32382778
http://dx.doi.org/10.1007/s00109-020-01916-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297861/
https://www.ncbi.nlm.nih.gov/pubmed/32382778
http://dx.doi.org/10.1007/s00109-020-01916-9

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