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Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke
ABSTRACT: Transforming growth factor-β-activated kinase 1 (TAK1) is upregulated after cerebral ischemia and contributes to an aggravation of brain injury. TAK1 acts as a key regulator of NF-ΚB and the MAP kinases JNK and p38 and modulates post-ischemic neuroinflammation and apoptosis. Microglia are...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297861/ https://www.ncbi.nlm.nih.gov/pubmed/32382778 http://dx.doi.org/10.1007/s00109-020-01916-9 |