In Pursuit of Stability Enhancement of a Prostate Cancer Targeting Antibody Derived from a Transgenic Animal Platform

Accelerated timelines necessitate the discovery of fully human antibodies as biotherapeutics using transgenic animals with a notion that such mAbs bypass humanization. A transgenic animal derived mAb (PCa75) targeted against a prostate cancer antigen had several ‘unusual residues’ (rare somatic hype...

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Detalles Bibliográficos
Autores principales: Venkataramani, Sathya, Ernst, Robin, Derebe, Mehabaw Getahun, Wright, Robert, Kopenhaver, Jessica, Jacobs, Steven A., Singh, Sanjaya, Ganesan, Rajkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298045/
https://www.ncbi.nlm.nih.gov/pubmed/32546687
http://dx.doi.org/10.1038/s41598-020-66636-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298045/
https://www.ncbi.nlm.nih.gov/pubmed/32546687
http://dx.doi.org/10.1038/s41598-020-66636-z

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