Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors

Effective T cell-based immunotherapy of solid malignancies requires intratumoral activity of cytotoxic T cells and induction of protective immune memory. A major obstacle to intratumoral trafficking and activation of vaccine-primed or adoptively transferred tumor-specific T cells is the immunosuppre...

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Detalles Bibliográficos
Autores principales: Albershardt, Tina C., Leleux, Jardin, Parsons, Andrea J., Krull, Jordan E., Berglund, Peter, ter Meulen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298055/
https://www.ncbi.nlm.nih.gov/pubmed/32579133
http://dx.doi.org/10.1038/s41541-020-0201-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298055/
https://www.ncbi.nlm.nih.gov/pubmed/32579133
http://dx.doi.org/10.1038/s41541-020-0201-x

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