Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil

BACKGROUND: The novel cap‐dependent endonuclease inhibitor baloxavir marboxil was approved in February 2018 for the treatment of influenza virus infection in Japan. In vitro studies have revealed that an I38T substitution in the polymerase acidic subunit (PA) is associated with reduced susceptibilit...

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Detalles Bibliográficos
Autores principales: Nakauchi, Mina, Takashita, Emi, Fujisaki, Seiichiro, Shirakura, Masayuki, Ogawa, Rie, Morita, Hiroko, Miura, Hideka, Saito, Shinji, Watanabe, Shinji, Odagiri, Takato, Kageyama, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298299/
https://www.ncbi.nlm.nih.gov/pubmed/32064779
http://dx.doi.org/10.1111/irv.12728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298299/
https://www.ncbi.nlm.nih.gov/pubmed/32064779
http://dx.doi.org/10.1111/irv.12728

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