rAAV8 and rAAV9-Mediated Long-Term Muscle Transduction with Tacrolimus (FK506) in Non-Human Primates

To establish an efficient, safe immunosuppressive regimen of adeno-associated vector (AAV)-mediated gene therapy for Duchenne muscular dystrophy (DMD), we evaluated the effect of tacrolimus (FK506) on skeletal muscle transduction with AAV8 and AAV9 vectors expressing the LacZ and microdystrophin (M3...

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Detalles Bibliográficos
Autores principales: Ishii, Akiko, Okada, Hironori, Hayashita-Kinoh, Hiromi, Shin, Jin-Hong, Tamaoka, Akira, Okada, Takashi, Takeda, Shin’ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298335/
https://www.ncbi.nlm.nih.gov/pubmed/32577431
http://dx.doi.org/10.1016/j.omtm.2020.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298335/
https://www.ncbi.nlm.nih.gov/pubmed/32577431
http://dx.doi.org/10.1016/j.omtm.2020.05.012

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