Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

STK19 was proposed to be a cancer driver, and recent work by Yin et al. (2019) in Cell suggested that the frequently recurring STK19 D89N substitution represents a gain-of-function change, allowing increased phosphorylation of NRAS to enhance melanocyte transformation. Here we show that the STK19 ge...

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Detalles Bibliográficos
Autores principales: Rodríguez-Martínez, Marta, Boissiére, Thierry, Gonzalez, Melvin Noe, Litchfield, Kevin, Mitter, Richard, Walker, Jane, Kjœr, Svend, Ismail, Mohamed, Downward, Julian, Swanton, Charles, Svejstrup, Jesper Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298618/
https://www.ncbi.nlm.nih.gov/pubmed/32531245
http://dx.doi.org/10.1016/j.cell.2020.04.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298618/
https://www.ncbi.nlm.nih.gov/pubmed/32531245
http://dx.doi.org/10.1016/j.cell.2020.04.014

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