Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products

Although insulin is a life-saving medicine, administration by daily injection remains problematic. Our goal was to exploit the power of DNA-encoded libraries to identify molecules with insulin-like activity but with the potential to be developed as oral drugs. Our strategy involved using a 10(4)-mem...

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Detalles Bibliográficos
Autores principales: Xie, Jia, Wang, Shuyue, Ma, Peixiang, Ma, Fei, Li, Jie, Wang, Wei, Lu, Fengping, Xiong, Huan, Gu, Yuang, Zhang, Shuning, Xu, Hongtao, Yang, Guang, Lerner, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298650/
https://www.ncbi.nlm.nih.gov/pubmed/32544667
http://dx.doi.org/10.1016/j.isci.2020.101197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298650/
https://www.ncbi.nlm.nih.gov/pubmed/32544667
http://dx.doi.org/10.1016/j.isci.2020.101197

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