Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients

BACKGROUND: 5-Fluorouracil (5-FU) and capecitabine are fluoropyrimidine derivatives that mainly metabolized with dihydropyrimidine dehydrogenase enzyme (DPD). The genetic polymorphism in the genes encoding this enzyme may result in a decrease or loss of enzyme activity which may lead to the accumula...

Descripción completa

Detalles Bibliográficos
Autores principales: Negarandeh, Reza, Salehifar, Ebrahim, Saghafi, Fatemeh, Jalali, Hossein, Janbabaei, Ghasem, Abdhaghighi, Mohammad Javad, Nosrati, Anahita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298798/
https://www.ncbi.nlm.nih.gov/pubmed/32546132
http://dx.doi.org/10.1186/s12885-020-06904-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298798/
https://www.ncbi.nlm.nih.gov/pubmed/32546132
http://dx.doi.org/10.1186/s12885-020-06904-3

Ejemplares similares